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Complexity occurs when we make things more dif cult than they have to be to avoid doing what we can do

You can add any KDE application to the KDE panel quite easily. Here s how: 1. Right-click an open space on the panel. 2. Choose Add Application. 3. Select one of the categories of applications. 4. Select any application from that category (or select Add This Menu to add the whole menu of applications). An icon representing the application immediately appears on the panel. (If the panel seems a bit crowded, you might want to remove some applications you don t use.) If you decide later that you no longer want this application to be available on the panel, right-click the edge of the icon and click the Remove button. To move it to a different location on the panel, right-click it, click Move, move it to where you want it on the panel, and click again.

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47 SUMMARY OF CHARGED-SPECIES PARTITIONING IN OCTANOL WATER Excluding effects not in the scope of this book, such as interfacial transport of charged species driven by electrical potentials, the main lesson of the partitioning studies of charged drugs is that the charged molecule needs to be accompanied by a counterion in order for the ion pair to enter a lipid phase such as octanol Later, it will become apparent that it must not be taken for granted that charged species enter other lipid phases as they do octanol The peculiar structure of octanol (Fig 28) may facilitate the entry of ion pairs in a way that may be impossible in a phospholipid bilayer, for example (covered below) Scherrer observed [280,281], as have others [161,162,275], that for a large number of ordinary charged species partitioning into octanol in the presence of aqueous solutions containing 015 M KCl or NaCl, weak-acid salts have values of diff log PN I equal to $4, and that weak-base salts have diff values equal to $3 These are helpful numbers to keep in mind when predicting the values of log PI when log PN is known Scherrer identi ed the conditions where diff 3 4 may be transgressed: (1) if the drug has several polar groups or a large polar surface over which charge can be delocalized, then smaller values of diff are observed; (2) hydroxyl groups adjacent to amines or carboxylic groups stabilize ion pairs, leading to lower diff values; and (3) steric hindrance to solvation leads to higher values of diff, as seen with tertiary amines, compared to primary ones [280,281]

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48 ION PAIR ABSORPTION OF IONIZED DRUGS FACT OR FICTION A review article with this title appeared in 1983 [369] It s an old question, one not fully resolved: What does the charged-species partitioning seen in octanol water systems have to do with biological systems If getting to the receptor site involves passing through many lipid membranes, and if the pH partition hypothesis is to hold, the answer to the question is a resounding Nothing If the active site is in the outer lea et of the apical membrane and the drug is orally introduced, or

TCP: TCP: TCP: TCP: TCP: TCP: TCP: TCP: TCP: TCP: TCP: TCP: Source port = 21 (FTP-ctrl) Destination port = 1034 Sequence number = 23344763 13 Next expected Seq number= 2334476374 Acknowledgment number = 916850913 Data offset = 20 bytes Reserved Bits: Reserved for Future Use (Not shown in the Hex Dump) Flags = 18 ..O. .... = (No urgent pointer) ...1 .... =Acknowledgment

We make things harder than they have to be By making things dif cult, we create struggle and prolong getting to where we want to be It s ironic when you think about it In order to appreciate the prize, we feel that we have to struggle to earn the prize Sure, it can be a lot of hard work, but it doesn t have to be complex Do you want to run a marathon Then go out and run a lot of training miles The solution isn t complex Complexity stalls us from our greatness It is the quicksand of our intentions 115

if ocular or skin absorption is considered [372,373], the answer is Maybe something We will return to this question in several instances in the next sections, for its answer warrants serious consideration

To use the MsgBox function, call it with the appropriate arguments and then test the return value. Here s an example, with the displayed dialog box shown in Figure 23.2:

FIGURE 9.1 The same FlowDocumentReader resized three times. Two columns are automatic when a page is resized wider than a minimum width.

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